Skin Rejuvenation & Mesotherapy
Skin rejuvenation with mesotherapy and Salmon-DNA (polynucleotide) treatments delivers hydrating and conditioning ingredients into the skin through fine micro-injections. Rather than adding volume, they aim to improve skin quality — boosting hydration, softening fine lines, easing dullness and supporting the look of skin affected by sun damage or acne scarring. Results are gradual and temporary, so maintenance is needed.
Medically reviewed by the Florence Healthcare medical team · Last reviewed June 2026
Overview
Mesotherapy and polynucleotide (Salmon-DNA) treatments focus on the quality of the skin rather than its shape. Using very fine needles, small amounts of a conditioning solution are placed into the upper layers of the skin across the treatment area. Mesotherapy solutions are typically based on hydrating hyaluronic acid with vitamins and other skin nutrients. Salmon-DNA treatments use polynucleotides, a purified injectable that helps improve dull, damaged skin, soften superficial wrinkles and support the appearance of skin affected by sagging, pigmentation or acne scarring.
Our dermatology team assesses your skin and goals and selects the most appropriate approach and formulation. These treatments are usually given as a short initial course of sessions spaced a few weeks apart, with improvements in hydration, brightness and smoothness building gradually. It is important to understand that the effect is a refreshment of skin quality, not a facelift or a volume filler, and that results are temporary — periodic maintenance sessions help sustain them.
For international patients, a coordinator arranges your consultation, an individual plan and a transparent, itemized cost estimate before travel. Our specialists can review clear photographs and your skin history remotely beforehand to suggest whether mesotherapy or a polynucleotide treatment fits your goals, so your visit can be planned efficiently.
Who is a candidate?
- Adults with dull, tired or dehydrated-looking skin wanting a refreshed appearance
- People bothered by fine lines or early skin laxity who are not seeking surgery
- Those wanting to improve the look of skin affected by sun damage or acne scarring
- Patients seeking a natural, gradual improvement in skin quality rather than added volume
- People able to attend a short course of sessions and periodic maintenance
- Those in good general health with realistic, non-surgical expectations
What happens
- 1
Consultation & skin assessment
A dermatologist reviews your skin, concerns, medical history and any medications, and discusses your goals. They advise whether mesotherapy, a polynucleotide (Salmon-DNA) treatment or another option best suits you, and outline the likely number of sessions.
- 2
Preparation
The area is cleaned and, if needed, topical numbing cream is applied for comfort. You are asked to mention any tendency to bruise, cold sores or allergies, and to avoid blood-thinning supplements where advised so bruising is minimized.
- 3
The treatment
Using very fine needles, small amounts of the chosen solution are injected across the treatment area. You may feel brief pinpricks; the session is short. Tiny bumps and mild redness immediately afterwards are normal and settle over the following hours to days.
- 4
Aftercare
You are advised on gentle skincare, avoiding makeup, heat, saunas and strenuous exercise for a day or so, and using sun protection. Your team reviews your response and schedules the next session in the course and any maintenance.
Benefits
- Aims to improve skin hydration, brightness and overall quality
- Can soften the look of fine lines and superficial wrinkles
- May improve the appearance of dull, sun-damaged skin and acne scarring
- Non-surgical, quick and typically with little downtime
- Gives a natural, gradual refreshment rather than an obvious change
Risks & considerations
- Temporary redness, swelling, small bumps or pinpoint bruising at injection sites
- Mild tenderness or itching in the treated area for a short time
- Rarely, infection, a small lump or a reaction to an ingredient
- Results are gradual and temporary; a course of sessions and ongoing maintenance are needed to sustain them
- It improves skin quality only — it does not replace volume or lift sagging skin the way surgery would
Conditions this treats
Where it is performed
This procedure is delivered by our Dermatology.
Learn more before you decide
Provider-reviewed guides on the related conditions, symptoms and tests in our Health Library.
Skin Rejuvenation & Mesotherapy — frequently asked questions
Both are delivered by fine micro-injections to improve skin quality rather than add volume. Mesotherapy solutions are usually hydrating blends of hyaluronic acid, vitamins and skin nutrients. Salmon-DNA treatments use polynucleotides, which help refresh dull, damaged skin, soften superficial wrinkles and support skin affected by pigmentation or acne scarring. Your dermatologist advises which suits your goals.
Numbing cream is used and most people find the fine injections very tolerable. Small bumps, mild redness or occasional pinpoint bruising are normal immediately afterwards and usually settle within a few days, so downtime is minimal.
Improvements in hydration, brightness and smoothness build gradually over your course of sessions rather than appearing overnight. The effect is temporary, so periodic maintenance sessions are recommended to sustain your results; your dermatologist will suggest a suitable interval.
No. These treatments improve the quality of the skin — hydration, tone and texture — and are not a volume filler or a surgical lift. If your goals involve restoring volume or contour, your dermatologist will discuss other options such as dermal fillers.
Yes. Our dermatology team can review clear photographs and your skin history remotely before you arrive to suggest whether mesotherapy or a polynucleotide treatment fits your goals and roughly how many sessions may be involved, so your visit is planned in advance.
We provide a transparent, itemized estimate after a consultation and do not quote fixed prices online, because the formulation, area and number of sessions are individual to you. Your coordinator confirms the details of your personalized plan before you commit.
Related treatments
Considering skin rejuvenation & mesotherapy?
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