Bone marrow is a spongy material found in the hollow centres of some bones. It is important as it contains special cells known as stem cells.
Stem cells create other specialised cells that carry out important functions. Stem cells in bone marrow produce three important types of blood cells:
Bone marrow transplantation (also known as stem cell transplantation) involves harvesting healthy stem cells to replenish the bone marrow of the patient. The new stem cells take over the production of the blood cells.
In some circumstances, it may be possible to take your own bone marrow from another part of your body (this is known as autologous transplantation). The bone marrow may be cleared of any diseased cells before being returned
There are five stages in the transplant process:
Stem cell transplantations are often required to treat conditions that have damaged the bone marrow which, as a result, can no longer produce normal blood cells. Any disruption to the production of blood cells can be very serious, particularly if:
Leukaemia is cancer of the white blood cells. The cancer causes the white blood cells to replicate in an uncontrollable manner and they do not develop any infection-fighting properties.
The cancerous cells can quickly spread through the bloodstream, resulting in a lack of room for red blood cells and platelets.
This leads to symptoms of anaemia, increases the risk of serious infection, and means that you will bruise and bleed more easily.
Non-Hodgkin's lymphoma is another type of cancer of the white blood cells. However, rather than spreading through the bloodstream, it spreads through the lymphatic system. The lymphatic system is a series of connected glands (nodes) that are spread throughout your body. It is an important part of your immune system, the body's natural defence against infection.
There are a number of genetic blood disorders where alterations (mutations) in your genes mean that blood cells do not develop normally. These include sickle cell anaemia and thalassaemia, both of which interfere with the production of red blood cells.
Stem cell transplants are normally only recommended if:
Over the years, thousands of patients diagnosed with leukemia, lymphoma, myelodysplasia, multiple myeloma and other blood cancers or disorders have come to the Group Florence Nightingale for many reasons— including that this is one of the most experienced transplant center in the world and our doctors can offer you access to the latest transplant research and techniques.