11-14 Test (Double Test)

Nuchal Translucency Ultrasound

This test, which is also known as the first trimester screening test, 11-14 test (double test), or nuchal translucency scan, involves ultrasonographic examination performed at 11 to 14 weeks of gestation, and assessing the risk of several fetal anomalies (e.g., Down syndrome) which are identified by laboratory screening tests on mother’s blood sample. After having the test, parents will be explained about the test results in detail.
What is Nuchal Translucency (NT) Scan?

Nuchal translucency is a collection of fluid under the skin at the back of the baby’s neck. It can be measured using ultrasound. Each baby has normally this fluid within certain limits. If an NT measurement gives higher results, this indicates that possibility for both chromosomal and structural disorders is increased.

Why is 11–14 scan is performed?

This ultrasound scan and test is performed to assess the risk for Down syndrome and other chromosomal anomalies; identify structural anomalies that fetus may have at that week; and to diagnose multiple pregnancies such as twin and triplet pregnancies, and asymptomatic pregnancy losses.

What does the 11–14 scan (double scan) involve? What is its percentage to identify the Down syndrome?

The 11-14 scan involves assessing the risk with mother’s age, blood levels of PAPP-A and Free Beta hCG measured for the mother, nuchal thickness of the fetus measured by ultrasound, nasal bone of the fetus, and blood flow in the baby’s heart and ductus venosus. The percentage of identifying the Down syndrome is around 97.5% with all these markers.

References

Yigiter AB, Kavak ZN, Durukan B, Isci H, Uzuner A, Uyar E, Gokaslan H. Placental volume and vascularization flow indices by 3D power Doppler US using VOCAL technique and correlation with IGF-1, free beta-hCG, PAPP-A, and uterine artery Doppler at 11-14 weeks of pregnancy. J Perinat Med. Mar;39(2):137-41, 2011.
Alin Basgul Yigiter, Z. N.Kavak, H.Isci, N.Guducu, B.Durukan. Prenatal diagnosis of a digynic triploid fetus in the second trimester: Transvaginal two-dimensional ultrasound, color Doppler and fetoplacental Doppler velocity waveform findings.” Clin Exp Obstet Gynecol. 38(3):303-5, 2011.
Alin Basgul Yigiter, Early normal and abnormal pregnancy .Donald School of Ultrasound in Obstetrics and Gynecology 2011.
Alin Başgül Yiğiter, Z.N. Kavak, N. Güdücü, H. Gökaslan ve E. Uyar, “Three Fetuses Karyotyped as Turner Syndrome with Cystic Hygroma Developing Hydrops: Prognosis and Outcome”, Clin Exp Obstet Gynecol,. 2007;34(3):182–4.
Kavak, Z.N., Alin Başgül Yiğiter, ve H. Gokaslan, “The Efficacy of First-trimester PAPP-A and Free Beta hCG Levels for Predicting Adverse Pregnancy Outcome”, J Perinat Med, 34, 2:145-148 (2006).
Alin Başgül Yiğiter, ve Z.N. Kavak, “Anne Karnında Down Sendromu Tanısına Güncel Yaklaşımlar ve Olgu Sunumu”, Aile Hekimliği Dergisi,10,4:178–82 (2006).
D. Sezen, Alin Başgül Yiğiter, Z. Kavak, H. Gökaslan, “ 11-14. Hafta Duktus Venozus Dopplerinin Nukal Kalınlık Ölçümü İle Birlikte Kullanımının Fetal Prognoza Etkileri”. Kadın Doğum Dergisi 4;4:941–5,2006.
Z. Abbas, Alin Başgül Yiğiter, Z. N. Kavak, S. Tokal, H. Gökaslan, “ 11-14. Gebelik Haftalarında Bakılan Uterin Arter Doppleri, Maternal Ekokardiyografi Ve Serum Belirteçlerinin Preeklampsi Ve İntrauterin Gelişme Geriliğini Tahminindeki Yeri”. Kadın Doğum Dergisi 4;4:935–40,2006.
Nicolaides KH. Screening for fetal aneuploidies at 11 to 13 weeks. Prenat Diagn. Jan;31(1):7-15,2011.
Alin Başgül Yiğiter, Z.N. Kavak, N. Bakirci ve H. Gokaslan, “Effect of Smoking on Pregnancy-associated Plasma Protein A, Free Beta-human Chorionic Gonadotropin, and Nuchal Translucency in the First Trimester of Pregnancy”, Adv Ther, 23, 1:131-138 (2006).
Alin Başgül Yiğiter, Z. N. Kavak, Y. Yılmaz, H. Gökaslan, A. Başgül, O. Tokol, H. Bengisu, “Predictive Value Of Umbilical Arterial Acid-Base Values, Biophysıcal Profıle Assessment And Apgar Score On Neurodevelopmental Outcome At Two Years In Normal Term Pregnancıes”. Zeynep Kamil Tıp Bülteni, 37,1,1–8 (2006).
Alin Başgül Yiğiter, Z. N. Kavak, “ Fetal Biofizik Profil”,Derleme. Kadın Doğum Dergisi, 3, 254–8 (2005).

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